First case of NDM-1-producing Acinetobacter baumannii isolated in Timor-Leste
DOI:
https://doi.org/10.33321/cdi.2022.46.65Keywords:
antimicrobial resistance, Acinetobacter baumannii, carbapenem antibiotics, Timor-Leste, NDM-1Abstract
Carbapenem antibiotics are important in the treatment of infections caused by bacteria in the order Enterobacterales which are resistant to multiple classes of antibiotics. Due to their high levels of intrinsic resistance, strains of Acinetobacter baumannii complex organisms resistant to carbapenems pose an important public health issue. Carbapenem-resistant A. baumannii (CRAB) is mainly due to acquisition of carbapenem-hydrolysing oxacillinase-encoding class D (OXA) genes which can be either plasmid- or chromosomally-encoded or through modification on the outer membrane protein and efflux pump. Although class B metallo-β-lactamases (MBLs) are not the most common mechanism of resistance seen in CRAB isolates, MBL-positive A. baumannii are increasingly reported worldwide. While this resistance mechanism was first described in an isolate of K. pneumoniae in 2008, many countries have since isolated strains of New Delhi metallo-beta-lactamase 1 (NDM-1) -carrying A. baumannii . We describe the first of these strains isolated in Timor-Leste.
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