Shigellosis: antibiotics should be strictly reserved for severe disease and cases at very high risk of onward transmission

Authors

  • Dr Bhakti R Vasant Metro South Public Health Unit, Building 5, 2404 Logan Road, Eight Mile Plains, QLD 4113; School of Public Health, University of Queensland, 266 Herston Road, Herston, QLD 4006; School of Medicine and Dentistry, Griffith University, 1 Parkland Drive, Southport, QLD 4215
  • Dr Mark Stickley Metro South Public Health Unit, Building 5, 2404 Logan Road, Eight Mile Plains, QLD 4113; School of Medicine, University of Queensland, 288 Herston Road, Herston, QLD 4006
  • Assoc. Prof. Megan Young School of Public Health, University of Queensland, 266 Herston Road, Herston, QLD 4006; School of Medicine and Dentistry, Griffith University, 1 Parkland Drive, Southport, QLD 4215; Metro North Public Health Unit, Building 4, Rosemount Campus, Bryden St, Windsor, QLD 4030
  • Dr Kate Alexander Gold Coast Public Health Unit, Building 1, Carrara Health Precinct, Carrara, QLD 4217
  • Mr Robert Bell Public Health Intelligence Branch, Queensland Health, 15 Butterfield Street, Herston, QLD 4006
  • Assoc. Prof. Amy V Jennison Public and Environmental Health Reference Laboratories, Queensland Health. 39 Kessels Road, Coopers Plains, QLD 4108
  • Dr Rikki Graham Public and Environmental Health Reference Laboratories, Queensland Health. 39 Kessels Road, Coopers Plains, QLD 4108
  • Dr Asha Kakkanat Public and Environmental Health Reference Laboratories, Queensland Health. 39 Kessels Road, Coopers Plains, QLD 4108
  • Dr Russell Stafford Public Health Intelligence Branch, Queensland Health, 15 Butterfield Street, Herston, QLD 4006

DOI:

https://doi.org/10.33321/cdi.2026.50.026

Keywords:

antimicrobial resistance, public health, shigellosis

Abstract

Increasing rates of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Shigella have been detected worldwide. This retrospective review of shigellosis notifications in Southeast Queensland found that XDR Shigella accounted for 48% of notifications. Antimicrobial treatment should be reserved for individuals with severe disease, immunocompromise or high risk of onward transmission.

Downloads

Download data is not yet available.

References

Baker S, Scott TA. Antimicrobial-resistant Shigella: where do we go next? Nat Rev Microbiol. 2023;21(7):409–10. doi: https://doi.org/10.1038/s41579-023-00906-1.

Therapeutic Guidelines. Shigella enteritis (shigellosis). Antibiotic. [Webpage.] Melbourne: Therapeutic Guidelines; March 2025. [Accessed in April 2025.] Available from: https://app.tg.org.au/viewTopic?etgAccess=true&guidelinePage=Antibiotic&topicfile=c_ABG_Shigella-enteritis-shigellosis_topic_1.

Siddiq M, O’Flanagan H, Richardson D, Llewellyn CD. Factors associated with sexually transmitted shigella in men who have sex with men: a systematic review. Sex Transm Infect. 2023;99(1):58–63. doi: https://doi.org/10.1136/sextrans-2022-055583.

Bourne A. Chemsex / party and play: challenging assumptions, responding to need. [Weblog article.] Sydney: Health Equity Matters website; 27 June 2018. [Accessed in January 2026.] Available from: https://www.healthequitymatters.org.au/resources/chemsex-party-and-play-challenging-assumptions-responding-to-need.

Australian Commission on Safety and Quality in Health Care (ACSQHC). National Alert System for Critical Antimicrobial Resistances (CARAlert) Laboratory Handbook. Sydney: ACSQHC; December 2022. [Accessed in April 2025.] Available from: https://www.safetyandquality.gov.au/publications-and-resources/resource-library/caralert-laboratory-handbook.

Communicable Diseases Network Australia (CDNA), Australian Centre for Disease Control (Australian CDC). Shigellosis – Surveillance case definition. Canberra: Australian CDC; 1 July 2018. [Accessed in May 2025.] Available from: https://www.cdc.gov.au/resources/publications/surveillance-case-definition-shigellosis.

Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020;75(12):3491–500. doi: https://doi.org/10.1093/jac/dkaa345.

Baumgart S, Phan T, McKew G. Epidemiology and antimicrobial resistance rates for Shigella species in a resource-rich setting. Pathology. 2025;57(1):94–9. doi: https://doi.org/10.1016/j.pathol.2024.07.004.

Williamson D, Ingle D, Howden B. Extensively drug-resistant shigellosis in Australia among men who have sex with men. N Engl J Med. 2019;381(25):2477–9. doi: https://doi.org/10.1056/NEJMc1910648.

Queensland State Government Department of Health (Queensland Health). Shigella Infection (Shigellosis). Queensland Health Guidelines for Public Health Units. [Webpage.] Brisbane: Queensland Health; July 2018. [Accessed in January 2026.] Available from: https://www.health.qld.gov.au/cdcg/index/shigellosis.

Charles H, Prochazka M, Thorley K, Crewdson A, Greig DR, Jenkins C et al. Outbreak of sexually transmitted, extensively drug-resistant Shigella sonnei in the UK, 2021–2022: a descriptive epidemiological study. Lancet Infect Dis. 2022;22(10):1503–10. doi: https://doi.org/10.1016/S1473-3099(22)00370-X.

Burns-Lynch C, Garcia-Williams A, Besrat B, Kachur R, Rosenberger J, Rutt C et al. A qualitative evaluation of the acceptability of shigellosis prevention recommendations among gay, bisexual, and other men who have sex with men. Sex Transm Dis. 2024;51(8):534–9. doi: https://doi.org/10.1097/OLQ.0000000000001968.

Jennison AV, Sherry NL, Howden BP. Enhanced data sharing and coordination to ensure Australia can address the threat of extensively drug-resistant Shigella – a case study for consideration by the Australian Centre for Disease Control. Commun Dis Intell (2018). 2025;49. doi: https://doi.org/10.33321/cdi.2025.49.064.

Dark and light blue shapes displaying the logo of Communicable Diseases Intelligence with a celebration graphic for Volume 50. The bottom of the cover features a lockup of the logo of the Australian Centre for Disease Control alongside the Commonwealth Coat of Arms.

Downloads

Published

24/03/26

How to Cite

Vasant, Bhakti, Mark Stickley, Megan Young, Kate Alexander, Robert Bell, Amy Jennison, Rikki Graham, Asha Kakkanat, and Russell Stafford. 2026. “Shigellosis: Antibiotics Should Be Strictly Reserved for Severe Disease and Cases at Very High Risk of Onward Transmission”. Communicable Diseases Intelligence 50 (March). https://doi.org/10.33321/cdi.2026.50.026.

Most read articles by the same author(s)

1 2 > >>