Queensland typhoid cluster linked to twelve-year carriage of Salmonella Typhi
DOI:
https://doi.org/10.33321/cdi.2022.46.27Keywords:
Salmonella, chronic carriage, S. TyphiAbstract
In September 2021, a household cluster of three typhoid cases was investigated by Queensland public health authorities. Through case interviews and molecular typing, the investigation revealed chronic carriage of Salmonella Typhi persisting at least 12 years in the index case. This case report summarises the investigation and highlights the complexity of chronic pathogen carriage in the control and management of typhoid disease. Our findings raise considerations for prevention and treatment guidelines in Australia and demonstrate the beneficial role of molecular typing for complex case investigations.
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Queensland Government. Typhoid and Paratyphoid Fever. [Internet.] Brisbane: Queensland Government; 9 April 2018. [Accessed on 12 November 2021.] Available from: http://conditions.health.qld.gov.au/HealthCondition/condition/14/33/146/typhoid-and-paratyphoid-fever.
Australian Government Department of Health. Typhoid and Paratyphoid Fevers: CDNA National Guidelines for Public Health Units. [Internet.] Canberra: Australian Government Department of Health; 15 March 2017. [Accessed on 12 November 2021.] Available from: https://www1.health.gov.au/internet/main/publishing.nsf/Content/cdna-song-typhoid-paratyphoid.htm.
Thanh Duy P, Thieu NTV, Nguyen Thi Nguyen T, Ngoc Dan Thanh H, Dongol S, Karkey A et al. Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi. PLoS Pathog . 2020;16(10):e1008998. doi: https://doi.org/10.1371/journal.ppat.1008998.
Gunn JS, Marshall JM, Baker S, Dongol S, Charles RC, Ryan ET. Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence. Trends Microbiol. 2014;22(11):648–55. doi: https://doi.org/10.1016/j.tim.2014.06.007.
Queensland Health. Typhoid and Paratyphoid (Enteric Fever). Notification procedure. [Internet.] Brisbane: Queensland Government, Queensland Health; 7 November 2014. [Accessed on 12 November 2021.] Available from: https://www.health.qld.gov.au/cdcg/index/typhoid#np.
Queensland Health. Notifiable conditions annual reporting. [Internet.] Brisbane: Queensland Government, Queensland Health; 2021. [Accessed on 12 November 2021.] Available from: https://www.health.qld.gov.au/clinical-practice/guidelines-procedures/diseases-infection/surveillance/reports/notifiable/annual.
Queensland Government. Public Health Act 2005 . [Legislation.] Brisbane: Queensland Government; 9 September 2021. [Accessed on 12 November 2021.] Available from: https://www.legislation.qld.gov.au/view/pdf/inforce/current/act-2005-048.
Queensland Health. Communicable Disease Control Manual: Typhoid and paratyphoid (enteric fever). Brisbane: Queensland Government; 2005.
Crump JA, Sjolund-Karlsson M, Gordon MA, Parry CM. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections. Clin Microbiol Rev . 2015;28(4):901–37. doi: https://doi.org/10.1128/CMR.00002-15.
Gal-Mor O. Persistent infection and long-term carriage of typhoidal and nontyphoidal Salmonellae . Clin Microbiol Rev . 2019;32(1). doi: https://doi.org/10.1128/CMR.00088-18.
Australian Government Department of Health. Australian Immunisation Handbook: Typhoid fever. [Internet.] Canberra: Australian Government Department of Health; 1 June 2018. [Accessed on 15 November 2021.] Available from: https://immunisationhandbook.health.gov.au/vaccine-preventable-diseases/typhoid-fever.
Yap KP, Thong KL. Salmonella Typhi genomics: envisaging the future of typhoid eradication. Trop Med Int Health . 2017;22(8):918–25. doi: https://doi.org/10.1111/tmi.12899.
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