Australian Meningococcal Surveillance Programme Annual Report, 2022
DOI:
https://doi.org/10.33321/cdi.2023.47.44Keywords:
antimicrobial resistance, disease surveillance, invasive meningococcal disease, Neisseria meningitidisAbstract
In Australia, both probable and laboratory-confirmed cases of invasive meningococcal disease (IMD) are reported to the National Notifiable Diseases Surveillance System (NNDSS). Compared to 2021, the number of IMD notifications in 2022 increased by 81% to 127, alongside the easing of COVID-19 containment measures. Laboratory confirmation occurred in 95% of these cases, with 51% (62/121) diagnosed by bacterial culture and 49% (59/121) by nucleic acid amplification testing. The serogroup was determined for 97% of laboratory-confirmed cases (117/121): serogroup B (MenB) accounted for 83% of infections (100/121); MenW for 4% (5/121); MenY for 10% (12/121); no infections were attributed to MenC disease. Fine typing was available on 67% of the cases for which the serogroup was determined (78/117). In MenB isolates, 27 porA types were detected, the most prevalent of which were P1.7-2,4 (18%;11/62), P1.22,14 (15%; 9/62), P1.18-1,34 (10%; 6/62) and P1.7,16-26 (10%; 6/62). All five MenW infections identified as porA type P1.5,2 with different MLST sequence types (ST): 11, 574, 1287, 12351, 13135 all belonging to clonal complex 11, the hypervirulent strain reported in outbreaks in Australia and overseas. In MenY, the predominant porA type was P1.5-1,10-1 (73%; 8/11), ST 1655 and from clonal complex 23.
Children less than 5 years of age and people aged 15–19 years were overrepresented with IMD notifications, accounting for 22% (27/121) and 23% (28/121) of laboratory-confirmed cases respectively. Fifteen percent of laboratory-confirmed notifications (18/121) were in persons aged 45–64 years. MenB infections were detected in all age groups but predominated in persons aged 15–19 years (93% of IMD in this age group; 26/28) and comprised 89% (24/27) of infections in children aged less than 5 years. MenW infections were markedly reduced in 2022, accounting for two IMD detections in children 1–4 years (2/16) and sporadic detections in other older age groups. MenY infections were largely detected in adults aged 45–64 years, accounting for 28% of IMD in this age group (5/18).
All 62 cultured IMD isolates had antimicrobial susceptibility testing performed. Minimum inhibitory concentration (MIC) values were categorised using Clinical Laboratory Standards Institute (CLSI) interpretative criteria: 5% (3/62) were defined as penicillin resistant (MIC value ≥ 0.5 mg/L); 71% (44/62) had intermediate susceptibility to penicillin (MIC values 0.125 and 0.25 mg/L) and 24% (15/62) were susceptible to penicillin. All isolates were susceptible to ceftriaxone, ciprofloxacin and rifampicin.
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References
National Neisseria Network. Meningococcal Isolate Surveillance Australia 1994. Commun Dis Intell. 1995;19(12):286–9.
Australian Government Department of Health and Aged Care. National Notifiable Diseases Surveillance System (NNDSS) data visualisation tool. [Webpage.] Canberra: Australian Government Department of Health and Aged Care; 14 December 2022. [Accessed on 10 May 2023.] Available from: https://www.health.gov.au/resources/apps-and-tools/national-notifiable-diseases-surveillance-system-nndss-data-visualisation-tool.
National Notifiable Diseases Surveillance System (NNDSS). Number of notifications of Meningococcal disease (invasive), received from State and Territory health authorities in the period of 1991 to 2012 and year-to-date notifications for 2014–2021. Available from: http://www9.health.gov.au/cda/source/rpt_4_sel.cfm.
Australian Government Department of Health and Aged Care. Invasive meningococcal disease. [Internet.] Canberra: Australian Government Department of Health and Aged Care; 12 July 2022. Available from: https://www.health.gov.au/internet/main/publishing.nsf/Content/ohp-meningococcal-W.htm.
Australian Government Department of Health and Aged Care, Communicable Diseases Network Australia (CDNA). Invasive Meningococcal Disease: CDNA National Guidelines for Public Health Units. Canberra: Australian Government Department of Health and Aged Care; 4 July 2017. Available from: https://www.health.gov.au/sites/default/files/documents/2020/02/invasive-meningococcal-disease-cdna-national-guidelines-for-public-health-units.pdf.
George CRR, Smith HV, Lahra MM. Neisseria meningitidis. In de Filippis I, ed. Molecular Typing in Bacterial Infections, Volume I. London: Springer International Publishing, Springer Cham, 2022;85–99.
Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing. 32nd ed. CLSI supplement M100. Wayne, PA: CLSI; 2022.
Lahra MM, George CRR, Hogan TR for the National Neisseria Network. Australian Meningococcal Surveillance Programme Annual Report, 2021. Commun Dis Intell (2018). 2022;46. doi: https://doi.org/10.33321/cdi.2022.46.46.
Abad R, López EL, Debbag R, Vázquez JA. Serogroup W meningococcal disease: global spread and current affect on the Southern Cone in Latin America. Epidemiol Infect. 2014;142(12):2461–70. doi: https://doi.org/10.1017/S0950268814001149.
Ladhani SN, Beebeejaun K, Lucidarme J, Campbell H, Gray S, Kaczmarski E et al. Increase in endemic Neisseria meningitidis capsular group W sequence type 11 complex associated with severe invasive disease in England and Wales. Clin Infect Dis. 2015;60(4):578–85. doi: https://doi.org/10.1093/cid/ciu881.
George CR, Booy R, Nissen MD, Lahra MM. The decline of invasive meningococcal disease and influenza in the time of COVID-19: the silver linings of the pandemic playbook. Med J Aust. 2022. doi: https://doi.org/10.5694/mja2.51463.
Chiu C, Dey A, Wang H, Menzies R, Deeks S, Mahajan D et al. Vaccine preventable diseases in Australia, 2005 to 2007. Commun Dis Intell Q Rep. 2010;34(Suppl):S1–167.
Australian Government Department of Health and Aged Care. Immunise Australia Program. Meningococcal Disease. [Internet.] Canberra: Australian Government Department of Health and Aged Care; 20 April 2015. Available from: https://www.health.gov.au/internet/immunise/publishing.nsf/Content/immunise-meningococcal.
Araya P, Fernández J, Del Canto F, Seoane M, Ibarz-Pavón AB, Barra G et al. Neisseria meningitidis ST-11 clonal complex, Chile 2012. Emerg Infect Dis. 2015;21(2):339–41. doi: https://doi.org/10.3201/eid2102.140746.
Bröker M, Jacobsson S, Kuusi M, Pace D, Simões MJ, Skoczynska A et al. Meningococcal serogroup Y emergence in Europe: update 2011. Hum Vaccin Immunother. 2012;8(12):1907–11. doi: https://doi.org/10.4161/hv.21794.
a Source: National Notifiable Diseases Surveillance System. Data extracted 10 May 2023.
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