Australian Rotavirus Surveillance Program: Annual Report, 2020
DOI:
https://doi.org/10.33321/cdi.2021.45.64Keywords:
rotavirus, gastroenteritis, genotype, surveillance, Australia, vaccine, Rotarix, COVID-19, diagnostic, notifiableAbstract
This report from the Australian Rotavirus Surveillance Network describes the circulating rotavirus genotypes identified in children and adults during the period 1 January – 31 December 2020. During this period, 229 faecal specimens were referred for rotavirus G- and P- genotype analysis, including 189 samples that were confirmed as rotavirus positive. Of these, 98/189 were wildtype rotavirus strains and 86/189 were identified as vaccine-like. A further five samples could not be determined as wildtype or vaccine-like due to poor sequence reads. Genotype analysis of the 98 wildtype rotavirus samples from both children and adults demonstrated that G3P[8] was the dominant genotype identified for the third consecutive year, identified in 27.6% of samples, followed by G2P[4] in 20.4% of samples. Forty-six percent of rotavirus positive samples received were identified as vaccine-like, highlighting the need to add caution in interpreting rotavirus positive results in children aged 0–8 months. This surveillance period was significantly impacted by the coronavirus disease 2019 ( COVID-19 ) pandemic. The reduction in rotavirus notifications reflected reduced healthcare-seeking behaviour and a decrease in community spread, with ‘community lockdowns’, school and day-care centre closure and improved compliance with hand hygiene. Fewer stool samples were collected throughout Australia during this period. There was a reluctance to store samples at collaborating laboratories and uncertainties regarding the safety and feasibility of the transport of samples to the central laboratory during the closure of state and territory borders. Systems have now been adapted to manage and send biological samples safely and confidently. Ongoing rotavirus surveillance is crucial to identify changes in genotypic patterns and to provide diagnostic laboratories quality assurance by reporting incidences of wildtype, vaccine-like, or false positive rotavirus results.
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References
Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr . 2018;172(10):958–65.
Immunization, Vaccines and Biologicals (IVB), World Health Organization (WHO). Vaccine in National Immunization Programme Update . [PowerPoint presentation.] Geneva: WHO; 27 October 2020. Available from: www.who.int/immunization/monitoring_surveillance/VaccineIntroStatus.ppt.
Buttery JP, Lambert SB, Grimwood K, Nissen MD, Field EJ, Macartney KK et al. Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia’s National Childhood vaccine schedule. Pediatr Infect Dis J . 2011;30(1 Suppl):S25–9.
Macartney KK, Porwal M, Dalton D, Cripps T, Maldigri T, Isaacs D et al. Decline in rotavirus hospitalisations following introduction of Australia’s national rotavirus immunisation programme. J Paediatr Child Health . 2011;47(5):266–70.
Reyes JF, Wood JG, Beutels P, Macartney K, McIntyre P, Menzies R et al. Beyond expectations: post-implementation data shows rotavirus vaccination is likely cost-saving in Australia. Vaccine . 2017;35(2):345–52.
Roczo-Farkas S, Cowley D, Bines JE, the Australian Rotavirus Surveillance Group. Australian Rotavirus Surveillance Program: Annual Report, 2017. Commun Dis Intell (2018) . 2019;43. doi: https://doi.org/10.33321/cdi.2019.43.28.
Australian Government Department of Health. Clinical update: ATAGI advice on Rotarix® to replace RotaTeq®. [Internet.] Canberra: Australian Government Department of Health; 20 December 2017. Available from: https://beta.health.gov.au/news-and-events/news/clinical-update-atagi-advice-on-rotarixr-to-replace-rotateqr.
Desselberger U. Rotaviruses. Virus Res . 2014;190:75–96.
Bányai K, László B, Duque J, Steele AD, Nelson EA, Gentsch JR et al. Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs. Vaccine . 2012;30(Suppl 1):A122–30.
Dóró R, László B, Martella V, Leshem E, Gentsch J, Parashar U et al. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? Infect Genet Evol . 2014;28:446–61.
Matthijnssens J, Ciarlet M, McDonald SM, Attoui H, Bányai K, Brister JR et al. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Arch Virol . 2011;156(8):1397–413.
Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Bányai K, Estes MK, et al. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Arch Virol . 2008;153(8):1621–9.
Taniguchi K, Urasawa S. Diversity in rotavirus genomes. Sem Virol . 1995;6(2):123–31.
Roczo-Farkas S, Kirkwood CD, Cowley D, Barnes GL, Bishop RF, Bogdanovic-Sakran N et al. The impact of rotavirus vaccines on genotype diversity: a comprehensive analysis of 2 decades of Australian surveillance data. J Infect Dis . 2018;218(4):546–54.
Gómara MI, Cubitt D, Desselberger U, Gray J. Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype. J Clin Microbiol . 2001;39(10):3796–8.
Simmonds MK, Armah G, Asmah R, Banerjee I, Damanka S, Esona M et al. New oligonucleotide primers for P-typing of rotavirus strains: strategies for typing previously untypeable strains. J Clin Virol . 2008;42(4):368–73.
Gentsch JR, Glass RI, Woods P, Gouvea V, Gorziglia M, Flores J et al. Identification of group A rotavirus gene 4 types by polymerase chain reaction. J Clin Microbiol . 1992;30(6):1365–73.
Gouvea V, Glass RI, Woods P, Taniguchi K, Clark HF, Forrester B et al. Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens. J Clin Microbiol . 1990;28(2):276–82.
Donato CM, Ch’ng LS, Boniface KF, Crawford NW, Buttery JP, Lyon M et al. Identification of strains of RotaTeq rotavirus vaccine in infants with gastroenteritis following routine vaccination. J Infect Dis . 2012;206(3):377–83.
Elschner M, Prudlo J, Hotzel H, Otto P, Sachse K. Nested reverse transcriptase-polymerase chain reaction for the detection of group A rotaviruses. J Vet Med B Infect Dis Vet Public Health . 2002;49(2):77–81.
Cowley D, Donato CM, Roczo-Farkas S, Kirkwood CD. Emergence of a novel equine-like G3P[8] inter-genogroup reassortant rotavirus strain associated with gastroenteritis in Australian children. J Gen Virol . 2016;97(2):403–10.
Australian Government Department of Health. National Notifiable Diseases Surveillance System. [Webpage.] Canberra: Australian Government Department of Health; 2021. [Accessed on 24 June 2021.] Available from: http://www9.health.gov.au/cda/source/rpt_1_sel.cfm.
Bruggink LD, Garcia-Clapes A, Tran T, Druce JD, Thorley BR. Decreased incidence of enterovirus and norovirus infections during the COVID-19 pandemic, Victoria, Australia, 2020. Commun Dis Intell (2018) . 2021;45. doi: https://doi.org/10.33321/cdi.2021.45.5.
Kuitunen I, Ponkilainen VT, Launonen AP, Reito A, Hevonkorpi TP, Paloneva J et al. The effect of national lockdown due to COVID-19 on emergency department visits. Scand J Trauma Resusc Emerg Med . 2020;28(1):114. doi: https://doi.org/10.1186/s13049-020-00810-0.
Australian Government Department of Health. Notification Rate for Rotavirus, Australia, in the period of 1991 to 2021 and year-to-date notifications for 2020. [Tabulation, updated 24 June 2021.] Canberra; Australian Government Department of Health. Available from: http://www9.health.gov.au/cda/source/rpt_3.cfm.
Bright A, Glynn-Robinson AJ, Kane S, Wright R, Saul N. The effect of COVID-19 public health measures on nationally notifiable diseases in Australia: preliminary analysis. Commun Dis Intell (2018) . 2020;44. doi: https://doi.org/10.33321/cdi.2020.44.85.
Adegbija O, Walker J, Smoll N, Khan A, Graham J, Khandaker G. Notifiable diseases after implementation of COVID-19 public health prevention measures in Central Queensland, Australia. Commun Dis Intell (2018) . 2021;45. doi: https://doi.org/10.33321/cdi.2021.45.11.
Hsieh YC, Wu FT, Hsiung CA, Wu HS, Chang KY, Huang YC. Comparison of virus shedding after lived attenuated and pentavalent reassortant rotavirus vaccine. Vaccine . 2014;32(10):1199–204.
Bennett A, Pollock L, Jere KC, Pitzer VE, Lopman B, Bar-Zeev N et al. Duration and density of fecal rotavirus shedding in vaccinated Malawian children with rotavirus gastroenteritis. J Infect Dis . 2019;222(12):2035–40.
Ye S, Whiley DM, Ware RS, Kirkwood CD, Lambert SB, Grimwood K. Multivalent rotavirus vaccine and wild-type rotavirus strain shedding in Australian infants: a birth cohort study. Clin Infect Dis . 2018;66(9):1411–8.
Hannet I, Engsbro AL, Pareja J, Schneider UV, Lisby JG, Pružinec-Popović B et al. Multicenter evaluation of the new QIAstat Gastrointestinal Panel for the rapid syndromic testing of acute gastroenteritis. Eur J Clin Microbiol Infect Dis . 2019;38(11):2103–12.
Celma CC, Beard S, Douglas A, Wong S, Osafo NK, Hannah M et al. Retrospective analysis on confirmation rates for referred positive rotavirus samples in England, 2016 to 2017: implications for diagnosis and surveillance. Euro Surveill . 2020;25(43). doi: https://doi.org/10.2807/1560-7917.ES.2020.25.43.1900375.
Whiley DM, Ye S, Tozer S, Clark JE, Bletchly C, Lambert SB et al. Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus. Clin Infect Dis . 2020;71(5):1324–6.
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