Learning from COVID-19: strengthening Australia’s research capacity through preparedness and collaboration

Authors

  • Miranda Z Smith Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
  • Janelle Bowden Access CR Pty Ltd, Sydney, New South Wales 2067, Australia
  • Linda Cristine Victorian Department of Health, Melbourne, Victoria 3000, Australia
  • Anthony L Cunningham Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales 2145, Australia; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2050, Australia
  • John Kaldor Kirby Institute, University of New South Wales, Kensington, New South Wales 2052, Australia
  • Sharon R Lewin Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
  • Andrew Singer Australian Government Department of Health and Aged Care, Canberra, Australian Capital Territory 2601, Australia; Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory 2601, Australia
  • Robyn L Ward Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2050, Australia
  • Tania C Sorrell Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2050, Australia

DOI:

https://doi.org/10.33321/cdi.2024.48.58

Keywords:

preparedness, research, pandemic, COVID-19, collaboration

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has highlighted that preparedness for and responsiveness to pandemics requires public health platforms and processes which are nimble and evidence-based and a research ecosystem which is rapidly responsive to the evolving needs of society and decision-makers. The national BEAT COVID-19 research consortium was funded in 2020 by the Snow Medical Research Foundation (Snow Medical). Its Expert Advisory Committee met with the consortium post-pandemic to summarise the research undertaken and to consider lessons learned through the research response to COVID-19 in Australia. The panel observed that philanthropy offered an important ‘kick-starter’ funding mechanism for urgent research, which facilitated leveraging of additional funds. It further agreed that research requirements for strengthening Australia’s pandemic preparedness and response include: (1) development of a national health and medical research strategy for pandemic research; (2) long-term investment in pre-established research partnerships and networks; (3) systemic procedural improvements, e.g. in ethics, governance and resource allocation; (4) responsive funding mechanisms including philanthropy; and (5) integration of research outputs into health practice and decision-making, as illustrated in Figure 1.

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References

Australian Government Department of the Prime Minister and Cabinet. Commonwealth Government COVID-19 Response Inquiry. [Webpage.] Canberra: Australian Government Department of the Prime Minister and Cabinet; 3 November 2023. Available from:

https://www.pmc.gov.au/domestic-policy/commonwealth-government-covid-19-response-inquiry.

Bowen AC, Tong SYC, Davis JS. Australia needs a prioritised national research strategy for clinical trials in a pandemic: lessons learned from COVID-19. Med J Aust. 2021;215(2):56–8 e1. doi: https://doi.org/10.5694/mja2.51143.

Straiton N, McKenzie A, Bowden J, Nichol A, Murphy R, Snelling T et al. Facing the ethical challenges: consumer involvement in COVID-19 pandemic research. J Bioeth Inq. 2020;17(4):743–8. doi: https://doi.org/10.1007/s11673-020-10060-5.

Australian Government Department of Health and Aged Care. National Health and Medical Research Strategy. [Webpage.] Canberra: Australian Government Department of Health and Aged Care; 25 June 2024. Available from:

https://www.health.gov.au/our-work/national-health-and-medical-research-strategy.

Chua AQ, Tan MMJ, Verma M, Han EKL, Hsu LY, Cook AR et al. Health system resilience in managing the COVID-19 pandemic: lessons from Singapore. BMJ Glob Health. 2020;5(9):e003317. doi: https://doi.org/10.1136/bmjgh-2020-003317.

United Kingdom Government Office for Science. National Core Studies programme. [Webpage.] London: United Kingdom Government Office for Science; 19 July 2021. Available from: https://www.gov.uk/guidance/national-core-studies-programme.

Munro APS, Feng S, Janani L, Cornelius V, Aley PK, Babbage G et al. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial. Lancet Infect Dis. 2022;22(8):1131–41. doi: https://doi.org/10.1016/S1473-3099(22)00271-7.

Patone M, Mei XW, Handunnetthi L, Dixon S, Zaccardi F, Shankar-Hari M et al. Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nat Med. 2022;28(2):410–22. doi: https://doi.org/10.1038/s41591-021-01630-0.

Australian Government Department of Health and Aged Care. MRFF governance. [Webpage.] Canberra: Australian Government Department of Health and Aged Care; 5 July 2024. Available from: https://www.health.gov.au/our-work/mrff/about/governance.

Smith MZ, Massey PD. Value of consultation in establishing a public health research network: lessons from APPRISE. Public Health Res Pract. 2021;31(5):31012102. doi: https://doi.org/10.17061/phrp31012102.

Thevarajan I, Nguyen THO, Koutsakos M, Druce J, Caly L, van de Sandt CE et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nat Med. 2020;26(4):453–5. doi: https://doi.org/10.1038/s41591-020-0819-2.

Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W et al. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) study. Rationale and design. Ann Am Thorac Soc. 2020;17(7):879–91. doi: https://doi.org/10.1513/AnnalsATS.202003-192SD.

Rockett RJ, Arnott A, Lam C, Sadsad R, Timms V, Gray KA et al. Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling. Nat Med. 2020;26(9):1398–404. doi: https://doi.org/10.1038/s41591-020-1000-7.

Vette KM, Machalek DA, Gidding HF, Nicholson S, O’Sullivan MVN, Carlin JB et al. Seroprevalence of severe acute respiratory syndrome coronavirus 2-specific antibodies in Australia after the first epidemic wave in 2020: a national survey. Open Forum Infect Dis. 2022;9(3):ofac002. doi: https://doi.org/10.1093/ofid/ofac002.

Tea F, Ospina Stella A, Aggarwal A, Darley DR, Pilli D, Vitale D et al. SARS-CoV-2 neutralizing antibodies: longevity, breadth, and evasion by emerging viral variants. PLoS Med. 2021;18(7):e1003656. doi: https://doi.org/10.1371/journal.pmed.1003656.

Lee E, Sandgren K, Duette G, Stylianou VV, Khanna R, Eden JS et al. Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity. J Virol. 2021;95(6):e02002-20. doi: https://doi.org/10.1128/JVI.02002-20.

Denholm JT, Davis J, Paterson D, Roberts J, Morpeth S, Snelling T et al. The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: a structured summary of a study protocol for a randomised controlled trial. Trials. 2020;21(1):646. doi: https://doi.org/10.1186/s13063-020-04576-9.

Hockham C, Kotwal S, Wilcox A, Bassi A, McGree J, Pollock C et al. Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial. Trials. 2021;22(1):573. doi: https://doi.org/10.1186/s13063-021-05521-0.

Crooks K, Taylor K, Law C, Campbell S, Miller A. Engage, understand, listen and act: evaluation of Community Panels to privilege First Nations voices in pandemic planning and response in Australia. BMJ Glob Health. 2022;7(8):e009114. doi: https://doi.org/10.1136/bmjgh-2022-009114.

Crooks K, Casey D, Ward JS. First Nations peoples leading the way in COVID-19 pandemic planning, response and management. Med J Aust. 2020;213(4):151–2.e1. doi: https://doi.org/10.5694/mja2.50704.

Seale H, Heywood AE, Leask J, Sheel M, Thomas S, Durrheim DN, et al. COVID-19 is rapidly changing: examining public perceptions and behaviors in response to this evolving pandemic. PLoS One. 2020;15(6):e0235112. doi: https://doi.org/10.1371/journal.pone.0235112.

Haire B, Gilbert GL, Kaldor JM, Hendrickx D, Dawson A, Williams JH. Experiences of risk in Australian hotel quarantine: a qualitative study. BMC Public Health. 2022;22(1):953. doi: https://doi.org/10.1186/s12889-022-13339-x.

Broom J, Broom A, Williams Veazey L, Burns P, Degeling C, Hor S et al. “One minute it’s an airborne virus, then it’s a droplet virus, and then it’s like nobody really knows...”: Experiences of pandemic PPE amongst Australian healthcare workers. Infect Dis Health. 2022;27(2):71–80. doi: https://doi.org/10.1016/j.idh.2021.10.005.

Robinson PA, Levy DC, Hooker C, Shaban RZ, Nahidi S, Leask J et al. COVID-19 testing decisions and behaviours in two Australian cities. Health Promot J Austr. 2022;34(2):587–94. doi: https://doi.org/10.1002/hpja.599.

Fredericks B, Bradfield A, McAvoy S, Ward J, Spierings S, Combo T et al. The burden of the beast: countering conspiracies and misinformation within Indigenous communities in Australia. M/C J. 2022;25(1). doi: https://doi.org/10.5204/mcj.2862.

Heris C, Chamberlain C, Woods C, Herrman H, Mohamed J, Kennedy M et al. 10 ways we can better respond to the pandemic in a trauma-informed way. [Internet.] Melbourne: The Conversation, The Conversation Media Group Ltd; 8 October 2021. Available from: https://theconversation.com/10-ways-we-can-better-respond-to-the-pandemic-in-a-trauma-informed-way-168486.

Australian Government Department of Health and Aged Care. Medical Research Future Fund (MRFF) grant recipients. [Webpage.] Canberra: Australian Government Department of Health and Aged Care; 2023. Available from: https://www.health.gov.au/resources/publications/medical-research-future-fund-mrff-grant-recipients.

UK Research and Innovation (UKRI). Two years on: the UK funded research that shaped the pandemic. [Internet.] Swindon: UKRI; 23 March 2022. Available from: https://www.ukri.org/news/two-years-on-the-uk-funded-research-that-shaped-the-pandemic/.

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Published

23/10/24

How to Cite

Smith, Miranda Z, Janelle Bowden, Linda Cristine, Anthony L Cunningham, John Kaldor, Sharon R Lewin, Andrew Singer, Robyn L Ward, and Tania C Sorrell. 2024. “Learning from COVID-19: Strengthening Australia’s Research Capacity through Preparedness and Collaboration”. Communicable Diseases Intelligence 48 (October). https://doi.org/10.33321/cdi.2024.48.58.

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