Measles with a possible 23 day incubation period
DOI:
https://doi.org/10.33321/cdi.2012.36.22Keywords:
measles, incubation period, elimination, epidemiology, genotypingAbstract
Measles virus (MV) eradication is biologically, technically and operationally feasible. An essential feature in understanding the chain of MV transmission is its incubation period, that is, the time from infection to the onset of symptoms. This period is important for determining the likely source of infection and directing public health measures to interrupt ongoing transmission. Long measles incubation periods have rarely been documented in the literature. We report on a previously healthy 11-year-old Australian boy who was confirmed with measles genotype D9 infection following travel in the Philippines. Epidemiological evidence supported an unusually long incubation period of at least 23 days and virological evidence was consistent with this finding. Although public health control measures such as post exposure prophylaxis, isolation and surveillance of susceptible individuals should continue to be based on the more common incubation period, a longer incubation period may occasionally explain an unexpected measles case. Commun Dis Intell 2012;36(3):E277–E280.
Downloads
References
Durrheim DN, Bashour H. Measles eradication. Lancet 2011;377(9768):808.
World Health Organization. Proceedings of the global technical consultation to assess the feasibility of measles eradication. J Infect Dis 2011(Suppl 1);204:S4–S13.
Heywood AE, Gidding HF, Riddell MA, McIntyre PB, MacIntyre CR, Kelly HA. Elimination of endemic measles transmission in Australia. Bull World Health Organ 2009;87(1):64–71.
Hummel KB, Lowe L, Bellini WJ, Rota PA. Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens. J Virol Methods. 2006;132(1–2):166–173.
Hall TA. In: BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symposium Series No. 41. Oxford University Press 1999;41:95–98.
Kessler JR, Kremer JR, Shugla SV, Tikhonova NT, Santibanez S, et al. Revealing new measles virus transmission routes by use of sequence analysis of phospoprotein and hemagglutinin genes. J Clin Microbiol 2011;49(2):677–683.
Goodson JL, Chu Sy, Rota PA, Moss WJ, Featherstone DA, Vijayaraghavan M, et al. Research priorities for global measles and rubella control and eradication. Vaccine 2012;30(32):4709–4716.
Kohlhagen JK, Massey PD, Durrheim DN. Meeting measles elimination indicators: surveillance performance in a regional area of Australia. Western Pacific J Surveill Response 2011;2:1–5.
Aaby P, Leeuwenburg J. Patterns of transmission and Severity of Measles Infection: A reanalysis of data from the Machakos Area, Kenya. J Infect Dis 1990;161(2):171–174.
Goodall EW. Incubation period of measles. BMJ 1931;1:73–74.
Sartwell PE. The distribution of incubation periods of infectious disease. Am J Hyg 1950;51(3):310–318.
Lessler J, Reich N, Brookmeyer R, Perl T, Nelson K, Cummings D. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 2009;9(5):291–300.
Thompoulos N, Johnson A. Tables and characteristics of the standardized lognormal distribution. Proceedings of the Decision Sciences Institute. 2003:1031–1036.
Fine P. The interval between successive cases of an infectious disease. Am J Epidemiol 2003;158(11):1039–1047.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2012 Communicable Diseases Intelligence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
